推荐回答(5个)
地塞米松是一种长效肾上腺糖皮质激素,近年来在兽医临床上被广泛应用,但由于一些基层兽医工作者不太了解地塞米松的药物特性,因此滥用现象十分严重,给养殖业者造成一定的经济损失,现就地塞米松的作用及应用中应注意的问题简述如下,供同行参考。
一、地塞米松的作用
1、抗炎作用地塞米松能够抑制嗜中性粒细胞向炎症部位的积聚,稳定溶酶体膜,收缩血管,降低血管的通透性,阻止溶酶体酶及炎症化学中介物质的合成和释放,增强细胞基质对粘多糖酸酶的抵抗力,抑制结缔组织的成纤维细胞增生和纤给细胞合成等达到抗炎作用。如用地塞米松治疗乳房炎、关节炎、腱鞘炎、粘液囊炎,各种眼炎(结膜炎、角膜炎、虹膜睫状体炎、周期性眼炎),肌肉、关节风湿病的急性期效果较好。
2、抗毒作用地塞米松能够保持细胞膜的完整性和降低细胞膜的通透性从而使细菌内毒素不易透入经胞内,起到保护机体的作用,因而地塞米松治疗严重的败血症、中毒性菌痢、中毒性肺炎、腹膜炎、产后急性子宫炎等,具有良好效果。
3、抗过敏作用地塞米松能够减少血液循环的T淋巴细胞、单核细胞、嗜酸性细胞,抑制巨噬细胞对抗原的摄联和处理,促使蛋白质异化,抑制蛋白质合成,影响抗体合成,达到抗过敏作用。因而用地塞米松治疗过敏性疾病,如荨麻诊、支气管哮喘、光过敏、急性蹄叶炎、过敏性皮炎、过敏性湿疹等效果较好。
4、抗体克作用地塞米松能够稳定机体的溶酶体膜,阻止溶酶体的释放,降低外周血管阻力,改善微循环阻滞,增加回心血量。因而用地塞米松治疗过敏性休克、创伤性休克、中毒性休克、心源性休克、低血容量休克等可起到良好作用。
5、对物质的代谢作用地塞米松可增强肝糖源异生作用,同时还能与胰岛素的作用拮抗,抑制葡萄糖氧化,使糖的利用率下降。因此用地塞米松治疗牛的酮血症和马、驴、羊妊娠毒血症有显著疗效。
二、应用时应注意的问题
1、地塞米松对炎症的治疗属非特异性作用,只能减轻或抑制炎症的表现,不能根本治疗,同时地塞米松还能降低机体的抗感染能力。因此,在治疗危及畜禽生命的感染性疾病时必须与足量有效地与抗菌药物同时配合应用;
2、地塞米松不能用于无有效抗菌药物治疗的病毒、霉菌、耐药菌株感染以及外毒素所引起的疾病;
3、地塞米松可使机体蛋白质异生和抑制蛋白质合成而影响抗体生成,影响疫苗免疫效价,降低免疫效果或引起免疫失败。因此,疫苗接种期、结核菌素、鼻菌素诊断期的畜禽禁用;
4、妊娠期母率禁用,地塞米松可通过胎盘,使胎盘功能不全,抑制胎儿的生长发育,造成畸形,甚至死亡。并且能兴奋子宫平滑肌,使子宫收缩,可引起妊娠母畜流产;
5、地塞米松可使机体代谢紊乱,减少钙磷在肠内的吸收,增加肾脏的排泄,影响骨质形成,幼年动物长期应用可影响生长发育或生长停止。因此,新生幼畜、骨软化病、骨质疏松症、骨折等疾病的病畜治疗应禁止使用;
6、禁止久用骤停,地塞米松久用可通过负反馈作用引起肾上腺皮质功能不全,药物减量过快或骤停,可发生肾上腺危象,病畜出现精神沉郁,食欲不振,呕吐,体温升高,软弱无力,低血压,低血糖,个别甚至出现休克等现象,使原有的疾病症状迅速复现或加重;
7、地塞米松可促进蛋白质分解,抑制蛋白质合成,延缓肉芽组织的形成,所以创伤或手术恢复期的家畜禁用。地塞米松也能兴奋刺激胃液分泌,降低胃肠黏膜的抵抗菌力,可诱发加重溃疡,有胃肠溃疡的畜禽疾病不宜应用;
8、地塞米松可引起低血钾、高血压、肌无力等,对心脏功能不全和严重心脏病的病畜不宜使用。地塞米松能引起动物兴奋、不安、激动,精神沉郁,狂燥等,尤以马属动物较为敏感,静脉注射时应缓慢,有严重狂燥病史的病畜应禁用;
9、注意药物配伍禁忌,地塞米松与氯化钙,磺胺嘧啶钠、盐酸四环素、盐酸土霉素、苯海拉明、氯丙嗪、异丙嗪、盐酸普鲁卡因等配伍易出现混浊或沉淀使药物失效;与水杨酸钠类药物合用可增加其毒性。
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