Traditional Chinese Medicine Identification is a traditional and ancient knowledge, along with the establishment and development of TCM, Chinese medicine authentication has become a systematic and comprehensive subject. In recent years, countries have developed traditional Chinese medicine modernization plan. To ensure the quality of traditional Chinese medicine, all kinds of modern identification methods are increasingly being identified in the application of traditional Chinese medicine. High performance liquid chromatography - mass spectrometry (HPLC-MS) combined with technology, HPLC separation of complex samples with high capacity and high selectivity of MS, high sensitivity and can provide the advantages of molecular weight and structure information can be combined on the quality of Chinese medicine for a more comprehensive evaluation. In this paper, HPLC-MS hyphenated techniques in recent years in Chinese herbal medicine and traditional Chinese medicine preparation Fingerprint application is reviewed